Persistent deficiency of myeloperoxidase and lactoferrin in granulopoietic cells of patients with acute leukemia.

Searching for prognostic factors which could help in the management of the therapy of human leukemia, we found marked cytochemical abnormalities in granulopoietic cells in plasma clot cultures of bone marrow and also peripheral blood cells of patients with acute leukemia [I]. We plotted the data of CFU-C colony/cluster ratio [2] versus MPO staining (Fig. 1) and found decrease, although these differences were not significant. CFU-C colony/cluster ratio versus colony number (Fig. 2) showed no significant difference although a slight decrease in colony numbers was suggestive. Using these data in a logistic regression analysis and plotting the percentual a posteriori probability of membership to a normal group versus the time after establishing